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Lawsuits Targeting Nexium, Prilosec, Prevacid Expose Their Dangers

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Millions of Americans take these proton pump inhibitors every day. For the first time, new studies show that proton pump inhibitors (PPIs) can have life-threatening side effects.  People taking them for a year or more are most at risk.  

Lawsuits:  Manufacturers failed to warn public 

Call Wayne Wright if a PPI has sickened you or a loved one.  Your call is free and so is our representation.  You only pay us if we recover for you.  Wayne Wright is one of the top 100 Trial Lawyers in America.  In 2014, he received a Litigator Award, the highest honor in Trial Law in the U.S.  It’s based on actual awards for clients.  Less than 1% of America’s lawyers ever win such substantial funds for those they represent to qualify for this rare honor.     

The seven most common PPIs include:

  • Omeprazole (Prilosec, Prilosec OTC)
  • Lansoprazole (Prevacid, Prevacid 24-Hour)
  • Dexlansoprazole (Dexilent, Kapidex)
  • Rabeprazole (Aciphex)
  • Pantropozole (Protonix)
  • Esomeprazole (Nexium)
  • Zegarid (a rapid release form of omeprazole)

Side Effects

PPIs caused a “96%increased risk of kidney failure compared to people who took alternatives…” according to a report in The Journal of the American Society of Nephrology.  Drug companies have not adequately warned the public about these new and other serious side effects of proton pump inhibitors:   

  • Acute interstitial nephritis (AIN)
  • chronic kidney disease (CKD)
  • Clostridium difficile infection
  • Dementia
  • Heart palpitations/heart attacks
  • Stevens Johnson Syndrome (SJS) Toxic Epidermal Necrolysis (TEN)
  • Low magnesium levels, convulsions
  • Osteoporosis and fractures of the hip, wrist and spine

Acute interstitial nephritis (AIN)

AIN is a life-threatening condition in which the kidney’s filters become inflamed.  It can cause irreversible kidney damage, leading to kidney failure.

Chronic kidney disease CKD)

The lack of symptoms and loss of function with CKD can be so slow that there are no symptoms until the kidneys have almost stopped working, letting wastes and fluids build up in the blood.  

Clostridium difficile infection (C diff)

C diff is a bacterium that can cause life-threatening inflammation and swelling of the colon.  It sickens an estimated 500,000 people in the U. S. every year.  It is becoming more frequent and difficult to treat.    


A new study shows that the incidence of dementia increases with age, particularly affecting individuals from 75 to 79 years of age who have taken the drug for 18 months or more.  

Heart palpitations and heart attacks 

New studies have found a connection to these cardiovascular events and the use of proton pump inhibitors even in people without a history of heart disease.

Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)

These skin disorders separate the top layer of the skin from the dermis; the lower level of the skin, causing severe blistering that can result in lengthy hospitalizations and infrequently results in death.   

Low magnesium levels

Magnesium helps regulate the heart and transmit signals from nerves.  Since 2011, the FDA has warned that PPIs can cause magnesium deficiencies.  Lack of magnesium causes seizures and muscle spasms.  

Osteoporosis and fractures

The FDA has found an increase in fractures with proton pump inhibitor use.

Proton Pump inhibitors became available more than 25 years ago. 

For years, the scientific community believed they were safe.   Recently, studies have linked them to a range of devastating, sometimes life-threatening conditions. (Read more)

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